Evidence and context
Ion Cyclotron Resonance Research Library
Ion Cyclotron Resonance Research Library
An on-site educational index of research related to Ion Cyclotron Resonance, SEQEX technology and broader extremely low-frequency electromagnetic-field research.
Important research context
The studies indexed here may involve laboratory models, medical conditions, research protocols or SEQEX devices that are distinct from the Ambrosia general-wellness system. Their inclusion is educational and does not establish that Ambrosia diagnoses, treats, cures, mitigates or prevents disease. No publication listed here establishes FDA approval, clearance, authorization or a medical intended use for Ambrosia. Study findings should be interpreted within their design, population, limitations and regulatory setting.
LifeLift educational reading
Start with accessible context
These summaries introduce recurring questions before readers explore the study index.
What Is Ion Cyclotron Resonance?
An introduction to ICR terminology, the underlying physical model and its place in electromagnetic-field research.
ICR and General PEMF
A conceptual comparison of targeted resonance approaches and broader pulsed electromagnetic-field categories.
Understanding Study Types
Why laboratory, animal, pilot, observational and randomized studies answer different questions and carry different limitations.
ICR and SEQEX research
Human, pilot and preclinical studies
Expand any entry for a concise, neutral description and a direct link to the exact article or authoritative record.
Effects of Extremely Low-Frequency Electromagnetic Field Treatment on ASD Symptoms in Children: A Pilot Study
Kierra Pietramala, Alessandro Greco, Alberto Garoli and Danielle Roblin
A pilot investigation evaluating symptom measures and safety observations in children exposed to an ELF-EMF protocol. The authors identify the need for broader samples and randomized controlled research.
The Effect of Extremely Low-Frequency Electromagnetic Fields on Inflammation and Performance-Related Indices in Trained Athletes
Irit Markus, Evyatar Ohayon, Keren Constantini, Keren Geva-Kleinberger, Rawan Ibrahim, Angela Ruban and Yftach Gepner
A double-blinded crossover study examining inflammatory and performance-related measurements in trained athletes following ELF-EMF exposure.
Chronic Drug-Resistant E. Coli Cystitis and Sequenced Extremely Low-Frequency Electromagnetic Fields
Ivan D’Agostino and F. Marelli
A randomized study of 148 cases comparing a sequenced electromagnetic-field protocol with placebo while tracking symptoms and laboratory parameters.
Effects of ELF-EMF Treatment on Depression
Gianluigi Carioni and Alessandro Greco
A preliminary assessment of a low-frequency, low-intensity electromagnetic-field protocol in people experiencing depression. It should be read as early-stage research, not evidence for Ambrosia use.
SEQEX Therapy in Osteonecrosis of the Femoral Head: A Case Report
Manuel Bondi, Matteo Benedini, Antonio Zanini and Andrea Pizzoli
A single case report describing conservative management involving a SEQEX protocol. Case reports cannot establish general effectiveness or causation.
Pulsed Extremely Low-Frequency Electromagnetic Fields in a Compression Spinal Cord Injury Model
Yona Goldshmit, Moshe Shalom and Angela Ruban
A preclinical mouse-model study examining inflammatory markers, astrocyte activation and neuroprotective signals after a spinal cord injury.
Low-Frequency Pulsed Electromagnetic Fields Following High-Intensity Exercise
Tel Aviv University research project
A double-blind crossover research project focused on inflammation and recovery-related performance measurements in trained cyclists.
ELF Magnetic Therapy and Oxidative Balance
Raggi, Vallesi, Rufini, Gizzi, Ercolani and Rossi
A small human study measuring malondialdehyde as an oxidative-stress marker before, after and one month following a SEQEX protocol.
ICR-Like and Osteoarthritis in Geriatric Patients: Pilot Study at an RCH Facility
Alessandro Greco, Nadia Malfatti, Valentina Lorengo, Elisabetta Zanella, Laura Sarnella, Iliara Frati and Nicolo Panza
An observational pilot study involving residents with osteoarthritis. Its small scale and design require cautious interpretation.
Ion Cyclotron Resonance: Results and Prospects for Psychiatry
Mario Betti, Marco Paolo Carlo Picchi, Marco Saettoni and Alessandro Greco
A discussion of the ICR-like model and a naturalistic observational assessment in psychiatric contexts. It relates to medical research, not Ambrosia’s general-wellness purpose.
Effects of Non-Focused ELF-EMF Treatment on EEG: Preliminary Study
Alessandro Greco and Alberto Garoli
A preliminary investigation using EEG measurements to examine central-nervous-system responses across several electromagnetic frequency ranges.
The Autistic Syndrome and Endogenous Ion Cyclotron Resonance
F. Crescentini
An early small observational report involving children and ICR-based support following other interventions. Its design does not support broad clinical conclusions.
Extremely Low-Frequency Electromagnetic Fields and Chemotherapy-Induced Myelotoxicity
E. Rossi, M. T. Corsetti, S. Sukkar and colleagues
Medical research examining ELF-EMF exposure in a chemotherapy-related context. This topic is outside Ambrosia’s general-wellness positioning.
Additional clinical publications
Further ICR, SEQEX and PEMF studies
This group includes prospective studies, preliminary investigations and older case reports. Case reports and uncontrolled observations can identify questions for future research, but they cannot establish effectiveness or predict individual outcomes.
Pulsed Electromagnetic Fields as a Tool in Orthognathic Surgery to Reduce Post-Operative Pain and Swelling
Friscia, Abbate, De Fazio, Sani, Spinelli, Troise and colleagues · 2024
A prospective observational study of 30 people following orthognathic surgery. It compared standard post-operative care with standard care plus PEMF delivered using a SEQEX FAM device. The small, non-randomized, single-centre design limits generalization.
Ion Resonance and Bromelain–Vitamin C Following Bimalleolar Ankle Surgery
Meccariello, Bello, Bove, Gagliardo, Raffaele and Matera · 2024
A three-group study involving 61 post-operative patients. Because ion resonance was combined with bromelain and vitamin C in one group, the study cannot isolate the contribution of each component.
Effects of Non-Focused ELF-EMF Treatment on Heart Rate Variability: Preliminary Study
Alessandro Greco and Anna Destefani · 2018
A single-blind preliminary study involving 46 healthy volunteers. It measured heart-rate-variability coherence during several ELF-EMF frequency configurations and requires confirmation in larger, independently replicated studies.
Effects of Cyclotronic Ion Resonance on Human Metabolic Processes: A Clinical Trial and One Case Report
Vallesi, Raggi, Rufini, Gizzi, Ercolani and Rossi · 2007
A study of 32 healthy volunteers measuring malondialdehyde and cholesterol before and after an ion-resonance protocol, accompanied by a case report. Its participant group and oxidative-stress measurements overlap closely with the separately indexed oxidative-balance publication.
Cyclotronic Ion Resonance Therapy and Arthralgia
Annantonia Ciafaloni · 2007
An uncontrolled report describing people with a range of musculoskeletal and neuromuscular concerns. The mixed population and absence of a randomized comparator prevent causal conclusions.
Endogenous Cyclotron Ion Resonance Therapy for Keratoconus: Preliminary Results
Matteo Belotti · 2007
A four-person preliminary report involving whole-body ICR exposure and local magnetic applicators. Its very small sample and uncontrolled design do not support general conclusions.
Utilization of Extremely Low-Frequency Magnetic Fields in Chronic Disease: Five Years’ Experience
Mancuso, Ghezzi and Di Fede · 2007
Three medical case reports describing ELF magnetic-field use, including use alongside other interventions. Case reports cannot separate treatment effects from other care, natural variation or measurement limitations.
Case Study: Amyotrophic Lateral Sclerosis
Cesare Santi and Alberto Turco · 2007
A single medical case report with no abstract available in PubMed. A single case cannot demonstrate effectiveness, safety across populations or a causal relationship.
Case Study: Peripheric Joint Disorders
Patrizia Castellacci · 2007
A brief case-series publication involving peripheral joint concerns. The report has no control group and should be interpreted as an early clinical observation.
Case Study: Eosinophilic Granuloma
Giuliano Zanni Campioli · 2007
A single published case with no abstract available in the indexed record. It cannot establish effectiveness or support conclusions about general-wellness use.
ICR-focused research
Mechanisms and cellular models
Resonant Convergence: An Integrative Model for Electromagnetic Interactions in Biological Systems
Alessandro Greco · International Journal of Molecular Sciences · 2025 · PMID 41516294 · DOI 10.3390/ijms27010423
This narrative review organizes several proposed explanations for interactions between weak electromagnetic fields and biological systems, including ICR-like and ion-parametric resonance models, quantum-electrodynamic hypotheses, thermomagnetic resonance and calcium–calmodulin signaling. It presents an integrative conceptual framework and calls for rigorous scientific examination; it is not a clinical trial of Ambrosia.
Disclosure: The author reports employment with S.I.S.T.E.M.I. srl, the manufacturer of SEQEX devices, in medical training and research and development. The published conflict-of-interest statement says the funders had no role in the review’s design, analysis, writing or publication decision.
Ion Cyclotron Resonance as a Tool in Regenerative Medicine
Lisi, Ledda, de Carlo, Pozzi, Messina, Gaetani, Chimenti and colleagues
Laboratory research examining electromagnetic-field exposure and differentiation-related markers in cardiac and osteogenic stem-cell models.
Effects of Endogenous Cyclotronic Ionic Resonance on Macular Diabetic Edema: Preliminary Results
P. D’Andrea and L. Maurizio
A preliminary medical investigation involving six patients and retinal-thickness measurement. The small sample prevents general conclusions.
PEMF and Fields Tuned to the Ion Cyclotron Resonance Frequency of Calcium in Chondrogenic Differentiation
Kavand, van Lintel and Renaud
A laboratory comparison of common PEMF parameters and calcium-tuned ICR conditions using cartilage-related cell differentiation markers.
Differentiation of Human Adult Cardiac Stem Cells Exposed to Extremely Low-Frequency Electromagnetic Fields
Gaetani, Ledda, Barile, Chimenti and colleagues
Cell-culture research assessing differentiation-related responses in human cardiac stem-cell preparations exposed to ELF-EMF conditions.
Physiological and Molecular Genetic Effects of Time-Varying Electromagnetic Fields on Human Neuronal Cells
Thomas J. Goodwin
Laboratory work using two- and three-dimensional neural progenitor-cell culture systems to examine growth and gene-expression patterns.
Broader research context
ELF-EMF and PEMF literature
These publications concern broader electromagnetic-field categories and should not be treated as Ambrosia-specific evidence.
Electromagnetic Field Therapy: A Rehabilitative Perspective in Musculoskeletal Pain
Paolucci, Pezzi, Centra, Giannandrea, Bellomo and Saggini
A systematic review of clinical literature on electromagnetic-field applications in rehabilitation for acute and chronic musculoskeletal pain.
Oscillating Electromagnetic Field Effects on Human Spermatozoon Motility: Preliminary Study
Iorio, Scrimaglio, Rantucci, Delle Monache and colleagues
A laboratory study comparing sperm-motility measurements under several ELF-EMF waveform and intensity conditions.
Biophysical Stimulation in Osteonecrosis of the Femoral Head
Leo, Milena, Ruggero, Stefania and colleagues
A publication reviewing biophysical stimulation approaches in a medical orthopedic context.
Electromagnetic Fields and Magnets: Investigational Treatment for Musculoskeletal Disorders
D. H. Trock
A clinical review discussing investigational electromagnetic approaches for musculoskeletal disorders.
Effectiveness of Pulsed Electromagnetic Field Therapy in Lateral Epicondylitis
Uzunca, Birtane and Taştekin
A randomized comparison involving active PEMF, sham PEMF and local steroid injection in people with lateral epicondylitis.
Effects of Pulsed Electromagnetic Fields on Articular Hyaline Cartilage
Fini, Giavaresi, Carpi, Nicolini, Setti and colleagues
A review of experimental and clinical literature involving PEMF exposure and articular-cartilage models.
Mechanisms and Therapeutic Applications of Electromagnetic Therapy in Parkinson’s Disease
Vadalà, Vallelunga and colleagues
A review of electromagnetic approaches in neurological research. It concerns medical therapies and is unrelated to Ambrosia wellness claims.
Modification of Osteoarthritis by Pulsed Electromagnetic Field: A Morphological Study
Ciombor, Aaron, Wang and Simon
Preclinical morphological research using an osteoarthritis animal model.
Expanding Use of Pulsed Electromagnetic Field Therapies
M. S. Markov
A broad review of PEMF modalities, parameters and reported applications across medical research.
Questions about the evidence?
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Ion Cyclotron Resonance education, Ambrosia onboarding and supported general-wellness use.
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